abstract：:To study the cytology profile of cervical smears and the respective prevalence and incidence of certain cervico-vaginal infections detectable by routine Pap smear cytology in Lebanese women from 2002 to 2006. Pap smear cytology results were compiled from the archives of the Institut National de Pathologie for the peri...

journal_title：Journal of biological regulators and homeostatic agents

authors： Karam WG,Rady A,Abdallah Hajj Hussein I,Assaad C,Saliba J,Aftimos G,Mortada M,Hazzouri M,Bedrossian N,Naji S,Leone A,Jurjus AR

更新日期：2011-07-01 00:00:00

abstract：:The early diagnosis and treatment of individuals harboring M. tuberculosis is key to ensuring the effectiveness of health programs aimed at the elimination of tuberculosis (TB). Monitoring for TB also has other important health care implications for the related immune pathology caused by the chronic inflammatory respo...

journal_title：Journal of biological regulators and homeostatic agents

authors： Bordignon V,Bultrini S,Prignano G,Sperduti I,Piperno G,Bonifati C,Filippetti M,Toma L,Latini A,Di Cecio M,Giuliani A,Vocaturo A,Trento E,D' Agosto G,Francesconi F,Cataldo A,Vento A,Cilenti V,Berardesca E,Ameglio F,

更新日期：2011-04-01 00:00:00

abstract：:Respiratory viral infections may worsen bronchial hyperreactivity. However, there is no data on the possible role of recurrent infectious rhinitis in nose hyperreactivity. This study was therefore designed to investigate whether subjects suffering from recurrent common cold have nasal hyperreactivity, assessed by hist...

journal_title：Journal of biological regulators and homeostatic agents

authors： Cassano M,Cassano P,Ciprandi G

更新日期：2011-04-01 00:00:00

abstract：:Many studies demonstrated that human adult cardiac progenitor cells in the form of cardiospheres (CSps) could represent a powerful candidate for cardiac cell therapy. To achieve the clinical translation of this biotechnological product, the development of well-defined culture conditions is required to optimize their p...

journal_title：Journal of biological regulators and homeostatic agents

authors： Fabrizi C,Angelini F,Chimenti I,Pompili E,Somma F,Gaetani R,Messina E,Fumagalli L,Giacomello A,Frati G

更新日期：2011-04-01 00:00:00

abstract：:Present data about hormonal regulation of haemostasis are often contradictory and are mostly based on clinical observations. The aim of the current research is to study the effects of the hormones of hypothalamic-pituitary-thyroid (HPT) axis on plasma levels (i.e. on the synthesis and secretion) of vitamin K-dependent...

journal_title：Journal of biological regulators and homeostatic agents

authors： Negrev N,Tashev R,Radev R,Anogeianaki A,Ivanova M

更新日期：2011-01-01 00:00:00

abstract：:Despite a wide range of available antidepressants, the effect of the treatment is often suboptimal and there is a need for more effective and better tolerated drugs. Unlike other antidepressants, agomelatine represents a new approach to depression with an innovative mechanism of action. It is an agonist of melatoniner...

journal_title：Journal of biological regulators and homeostatic agents

authors： Di Giannantonio M,Di Iorio G,Guglielmo R,De Berardis D,Conti CM,Acciavatti T,Cornelio M,Martinotti G

更新日期：2011-01-01 00:00:00

abstract：:The early detection of genomic biomarkers (e.g. RNAs) through analysis of circulating blood cells could have a substantial impact on biomedicine, particularly in monitoring clinical trials, drug toxicity and doping in athletes. To achieve this goal, it is essential to develop methods that are sufficiently sensitive to...

journal_title：Journal of biological regulators and homeostatic agents

authors： Minella D,Biancolella M,Testa B,Prosperini G,Zenobi R,Novelli G,Giganti MG

更新日期：2010-10-01 00:00:00

abstract：:Given the high sensitivity of the male reproductive system to oxidative stress and to temperature changes, the amount of germ cell apoptosis and the activation of the poly(ADP-ribosyl)ation system (a very sensitive index of genotoxic stress) were evaluated in the testicular tissue of adult rats which underwent a 10-wk...

journal_title：Journal of biological regulators and homeostatic agents

authors： Faraone-Mennella MR,Marini M,Ferone A,Cacace O,Liguoro A,Margonato V,Farina B,Veicsteinas A

更新日期：2010-07-01 00:00:00

abstract：:Stem cells are a promising tool for bone tissue regeneration. Dental pulp stem cells (DPSCs) can be easily obtained even in human young adults. In this study we investigated the capability of DPSCs, to express the osteoblastic phenotype when cultured with osteogenic medium. DPSCs isolated from the dental pulp of impac...

journal_title：Journal of biological regulators and homeostatic agents

authors： Mori G,Centonze M,Brunetti G,Ballini A,Oranger A,Mori C,Lo Muzio L,Tetè S,Ciccolella F,Colucci S,Grano M,Grassi FR

更新日期：2010-04-01 00:00:00

abstract：:Diabetic nephropathy (DN) is a severe and life-threatening complication of long-standing diabetes. As one of the main causes of end-stage renal disease, the prevention and treatment of DN in early stage, and the slowing down of DN progression are of utmost importance and are topics of several ongoing research studies....

journal_title：Journal of biological regulators and homeostatic agents

authors： Marotta F,Harada M,Dallah ED,Yadav H,Solimene U,Di Lembo S,Minelli E,Jain S,Chui DH

更新日期：2010-01-01 00:00:00

abstract：:There is a great hazard of mercury intoxication in the third world for artisanal miners using mercury as amalgam for extracting and refining gold. In developing countries, there is the possibility of risk regarding exposure to Hg from amalgam tooth fillings, ethyl-Hg (thimerosal) added as antiseptic to vaccines and me...

journal_title：Journal of biological regulators and homeostatic agents

authors： Boscolo M,Antonucci S,Volpe AR,Carmignani M,Di Gioacchino M

更新日期：2009-10-01 00:00:00

abstract：:IL-32, a newly-discovered proinflammatory cytokine that activates the p38MAPK and NF-kappaB pathways, is an important player in innate and adaptive immune response. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the productio...

journal_title：Journal of biological regulators and homeostatic agents

authors： Felaco P,Castellani ML,De Lutiis MA,Felaco M,Pandolfi F,Salini V,De Amicis D,Vecchiet J,Tete S,Ciampoli C,Conti F,Cerulli G,Caraffa A,Antinolfi P,Cuccurullo C,Perrella A,Theoharides TC,Conti P,Toniato E,Kempuraj D,

更新日期：2009-07-01 00:00:00

abstract：:Adenoidal hypertrophy (AH) represents one of the most frequent indications for surgery in children. Recently, treatment with intranasal corticosteroids has been suggested to decrease the size of AH. The aim of the study is to evaluate the long-term effect of intranasal flunisolide on AH during a 12-month follow-up. On...

journal_title：Journal of biological regulators and homeostatic agents

authors： Varricchio A,Tortoriello G,Capasso M,De Lucia A,Marchisio P,Varricchio AM,Mansi N,Giordano L,Liberatore G,Di Gioacchino M,Ciprandi G

更新日期：2009-04-01 00:00:00

abstract：:Intravenous IgG has been adopted as treatment for various immune-related diseases, including immune thrombocytopenic purpura, autoimmune neuropathies, systemic lupus erythematosus, Guillain-Barré syndrome, myasthenia gravis, Kawasaki disease, skin blistering diseases. The intravenous administration of exogenously pool...

journal_title：Journal of biological regulators and homeostatic agents

authors： Luzi G,Bongiorno F,Paparo Barbaro S,Bruno G

更新日期：2009-01-01 00:00:00

abstract：:This study highlights the close link between upper and lower airways and the relevance of bronchodilation test in patients presenting with moderate-severe persistent allergic rhinitis and mild persistent asthma. ...

journal_title：Journal of biological regulators and homeostatic agents

authors： Marseglia GL,Marchi A,Caimmi D,Caimmi S,Di Gioacchino M,Ciprandi G

更新日期：2008-10-01 00:00:00

abstract：:Allergic rhinitis (AR) is characterized by Th2 polarized immune response. Allergen-specific subcutaneous immunotherapy may restore a physiologic Th1 profile. However, there are few studies investigating the immunological effects of sublingual immunotherapy (SLIT). The aim of this study is to investigate whether a pre-...

journal_title：Journal of biological regulators and homeostatic agents

authors： Ciprandi G,Fenoglio D,Di Gioacchino M,Ferrera A,Ferrera F,Sormani MP,Marseglia GL

更新日期：2008-07-01 00:00:00

abstract：:Much evidence suggests a cross-talking between nerve fibers and the immunity system. The immunomodulation by substance P includes cell activation and proliferation of human cells, with cytokine and chemokine generation and release. Substance P was first isolated by Leeman et al. as an undecapeptide with important neur...

journal_title：Journal of biological regulators and homeostatic agents

authors： Katsanos GS,Anogeianaki A,Orso C,Tete S,Salini V,Antinolfi PL,Sabatino G

更新日期：2008-04-01 00:00:00

abstract：:Three main types of inflammatory Non-Allergic Rhinitis (NAR) have been defined: NAR infiltrated by eosinophils (NARES), by mast cells (NARMA), and by neutrophils (NARNE). In the absence of studies that investigated the Quality of Life (QoL) in NAR, the present work is aimed at evaluating the Quality of Life of patient...

journal_title：Journal of biological regulators and homeostatic agents

authors： Gelardi M,Maselli Del Giudice A,Fiorella ML,Soleti P,Di Gioacchino M,Conti CM,Fulcheri M,Doyle R,Ciprandi G

更新日期：2008-01-01 00:00:00

abstract：:Free radical damage to many cellular components has been proposed as the main mechanism underlying the aging process. In the liver, NO can be generated by iNOS, but also by the constitutively expressed endothelial NOS (eNOS). iNOS enzyme appears to be expressed in liver disease such as cirrhosis and fulminant hepatiti...

journal_title：Journal of biological regulators and homeostatic agents

authors： Patruno A,Speranza L,Tetè S,Mastrangelo F,De Lutiis MA,Pesce M,Franceschelli S,Vinciguerra I,Felaco M,Grilli A

更新日期：2007-01-01 00:00:00

abstract：:The aim of this study is to evaluate the efficacy of a nifedipine gel in patients with primary or secondary Raynaud?s phenomenon. Photopletismography was the instrumental examination test used to evaluate recovery time (time necessary for recuperation of normal capillary circulation) in 17 patients with primary or sec...

journal_title：Journal of biological regulators and homeostatic agents

authors： Foti C,Quaranta D,Pepe ML,Morea G,Mastropasqua D,D'Amore M,Mastrangelo F,Tete S,Grassi FR,Ballini A,Salini V,De Amicis D,Scagliusi P,De Lutiis MA,Caraffa A,Cerulli G

更新日期：2006-07-01 00:00:00

abstract：:Regulated on activation, normal T-cell expressed and presumably secreted (RANTES), which generally mediates monocyte-macrophage (MO) activation and recruitment, is a protein of 8-10 kD that chemoattracts eosinophils, monocytes and certain T leukocyte subsets. RANTES is coded for by a gene cluster located on human chro...

journal_title：Journal of biological regulators and homeostatic agents

authors： Shanmugham LN,Petrarca C,Castellani ML,Frydas S,Vecchiet J,Conti P,Tete S

更新日期：2006-01-01 00:00:00

abstract：:An anti-CD38 mAb (IB4) coupled to saporin-S6, a type 1 ribosome-inactivating protein (RIP), was designed for ex vivo or loco-regional therapeutical applications in myeloma and lymphoma. The ability of this immunotoxin to eliminate CD38+ cells was studied in vitro on selected CD38+ human cell lines (Raji, HBL6, L540 an...

journal_title：Journal of biological regulators and homeostatic agents

authors： Bolognesi A,Polito L,Farini V,Bortolotti M,Tazzari PL,Ratta M,Ravaioli A,Horenstein AL,Stirpe F,Battelli MG,Malavasi F

更新日期：2005-07-01 00:00:00

abstract：:B cell antigen receptor (BCR) engagement results in the assembly of a multimolecular complex at the cytosolic side of the plasma membrane, known as signalosome. Here we briefly review the current knowledge on the molecules which participate in the BCR signalosome and on the response modulators which control the final ...

journal_title：Journal of biological regulators and homeostatic agents

authors： Ulivieri C,Baldari CT

更新日期：2005-01-01 00:00:00

abstract：:Immunocytochemical detection of isolated tumor cells in peripheral blood and bone marrow is currently the most established method for monitoring early dissemination in epithelial cancer. In this study we used an immunomagnetic selection technique to develop an enrichment model for disseminated tumor cells in blood. Bu...

journal_title：Journal of biological regulators and homeostatic agents

authors： Brooimans RA,de Leeuw N,Bontenbal M,Gratama JW

更新日期：2005-01-01 00:00:00

abstract：:It has been postulated that host factors, such as the human leucocyte antigen (HLA) system, may play a predominant role in the pathogenesis of HCV-related extra-hepatic manifestations. This study was performed to investigate the role of HLA- DR and DQ alleles in a group of Italian patients, with HCV infection and asso...

journal_title：Journal of biological regulators and homeostatic agents

authors： Sebastiani GD,Bellisai F,Caudai C,Rottoli P,Valensin PE,Pippi L,Morozzi G,Porciello G,Donvito A,Bilenchi R,Giannini F,Galeazzi M

更新日期：2005-01-01 00:00:00

abstract：:Several phenotypic changes have been shown to occur after NK-cell stimulation, involving molecules that have been proved to regulate NK-cell migration into tissues and NK-cell activation and proliferation as well as target cell recognition and killing. Here, we review the reactive phenotypes observed in vivo after acu...

journal_title：Journal of biological regulators and homeostatic agents

authors： Lima M,Almeida J,Teixeira MA,Santos AH,Queirós ML,Fonseca S,Moura J,Gonçalves M,Orfão A,Pinto Ribeiro AC

更新日期：2004-07-01 00:00:00

abstract：:Radiation is energy transfer. When radiation has sufficient energy to remove an orbital electron from its atom, an ionized atom is formed, and radiation with the capacity to do this is called ionizing radiation. The primary effect of radiation is the induction of free radicals and Reactive Oxygen Species (ROS). All th...

journal_title：Journal of biological regulators and homeostatic agents

authors： De Saint-Georges L

更新日期：2004-04-01 00:00:00

abstract：:Identifying and characterizing the earliest stages of disease is particularly important in disorders such as Chronic Lymphocytic Leukemia (CLL), where the initiating oncogenic events are unknown. Improvements in diagnostic technology have led to the detection of disease-associated markers in increasing numbers of othe...

journal_title：Journal of biological regulators and homeostatic agents

authors： Rawstron AC

更新日期：2004-04-01 00:00:00

abstract：:If real-time PCR is to be of much worth to its user, some idea regarding the reliability of its data is essential. We discuss here some of the problems associated with interpreting numerical real-time PCR data that lend themselves to analytical evaluation. We translate into the language of molecular biology some of th...

journal_title：Journal of biological regulators and homeostatic agents

authors： Vaerman JL,Saussoy P,Ingargiola I

更新日期：2004-04-01 00:00:00

abstract：:The aim was to confirm the influence of HLA Class II antigens on the progression of HCV infection and to assess the relationship between these antigens and histological damage, HCV viral load and HCV genotype. 143 patients were enrolled and divided into three groups. Group A included 34 anti-HCV positive, HCV-RNA nega...

journal_title：Journal of biological regulators and homeostatic agents

authors： Scotto G,Fazio V,D'Alessandro G,Monno L,Saracino A,Palumbo E,Angarano G

更新日期：2003-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a common transmissible agent responsible for a significant proportion of chronic liver disease, cirrhosis and hepatocellular carcinoma worldwide. The natural history of acute HCV infection is characterized by a high rate of progression to persistent infection. The resulting chronic liver dis...

journal_title：Journal of biological regulators and homeostatic agents

authors： Mondelli MU

更新日期：2003-04-01 00:00:00

abstract：:A complete understanding of the molecular features of humoral immune response could be of pivotal importance in the management of persistent viruses as HCV. In this study, 24 HCV-positive samples, characterized by classical virological parameters, are evaluated using a new assay for the quantitation of antibody subpop...

journal_title：Journal of biological regulators and homeostatic agents

authors： Mancini N,Canducci F,Carletti S,Berardinelli E,Serafini G,Grieco A,Perotti M,Malcangi G,Danieli MG,Varaldo PE,Clementi M,Burioni R

更新日期：2003-04-01 00:00:00

abstract：:Retinoid X Receptors (RXRs) consist of a family of nuclear receptors that target and regulate multiple signalling pathways. The early evolutionary emergence of RXRs in comparison to other nuclear receptors may have allowed for the development of unique properties as transcriptional regulators. Indeed, the complexity o...

journal_title：Journal of biological regulators and homeostatic agents

authors： Ahuja HS,Szanto A,Nagy L,Davies PJ

更新日期：2003-01-01 00:00:00

abstract：:A cross-talk between dendritic cells (DC) and resting natural killer (NK) cells leads to the activation of both cell populations, a process requiring cell-cell contact. When the number of activated NK cells overwhelms surrounding DC, they became able to kill specifically immature DC, a feedback mechanism to shut off D...

journal_title：Journal of biological regulators and homeostatic agents

authors： Fortis C,Tasca S,Capiluppi B,Tambussi G

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:A vast majority of HIV-infected subjects who experience HIV acute seroconversion actually receive treatment. Open questions are how can we identify patients who will be slow progressors or long-term non progressors, and, as a consequence, do not require treatment. METHODS:An observational retrospective stud...

journal_title：Journal of biological regulators and homeostatic agents

authors： Mussini C,Cozzi-Lepri A,Bedini A,Borghi V,Mongiardo N,Cossarizza A,Esposito R

更新日期：2002-01-01 00:00:00

abstract：:To investigate percutaneous exposures to HIV in the highly active antiretroviral therapy (HAART) era, we performed an analysis of all percutaneous exposures reported from January 1994 to December 1998 in 18 Italian acute-care hospitals. Frequency and rate per 100 prevalent AIDS cases of HIV exposures decreased by 40% ...

journal_title：Journal of biological regulators and homeostatic agents

authors： De Carli G,Puro V,Petrosillo N,Finzi G,Ferraresi I,Daglio M,Amoddeo C,Bombonato M,Bertucci R,Maccarrone S,Raineri G,Desperati M,Contegiacomo P,Penna C,Fulgheri M,Nelli M,Rebora M,Fasulo G,Bonaventura ME,Segata A,M

更新日期：2001-07-01 00:00:00

abstract：:A high heterogeneity is found in the HIV-1 genome in vivo, not only between individuals, but also within a single individual. Different types of genetic heterogeneity of HIV-1 can be analyzed: the extension and the evolution of the viral quasispecies in blood, the variation between the virus obtained from different bo...

journal_title：Journal of biological regulators and homeostatic agents

authors： Visco-Comandini U,Aleman S,Yun Z,Sönnerborg A

更新日期：2001-07-01 00:00:00

abstract：:Transmembrane proteases (i.e. membrane-associated proteases, ectoproteases) are present in a wide variety of tissues and cell types including endothelial, epithelial and hematopoietic cells. Natural and synthetic inhibitors have been characterized and have revealed that certain ectoenzymes are able to modulate bioacti...

journal_title：Journal of biological regulators and homeostatic agents

authors： Antczak C,De Meester I,Bauvois B

更新日期：2001-04-01 00:00:00

abstract：:Flow cytometric enumeration of CD34+ hematopoietic stem and progenitor cells (HPC) is widely used for evaluation of graft adequacy of peripheral blood stem cell grafts, and is also useful in planning the apheresis sessions necessary to obtain these grafts. The state-of-the-art method to enumerate CD34+ cells makes use...

journal_title：Journal of biological regulators and homeostatic agents

authors： Gratama JW,Sutherland DR,Keeney M,Papa S

更新日期：2001-01-01 00:00:00

abstract：:Somatically acquired genetic alterations play an important role in the pathogenesis of acute lymphoblastic leukemia. The molecular analysis of these alterations has increased our understanding of the mechanisms of leukemogenesis. In addition, this information has led to improvements in our abilities to predict treatme...

journal_title：Journal of biological regulators and homeostatic agents

authors： Rubnitz JE

更新日期：2000-07-01 00:00:00